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Specific assay kits designed measure the activation levels of small, active GTPases by isolating them via their specific downstream effectors. Kits employ molecular methods including pull-down affinity purification, electrophoresis, and western blotting.
Lipid CP-LC-1074 is an ionizable cationic amino lipid derived from homocysteine a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA cRNA and saRNA)in vivo. Moreover using a typical LNP formulation (IL/Ch/DOPE/PEG 50/38.5/10/1.5) it has shown to induce specific lung targeting much more efficiently that other commercial alternatives throUGh IV injection with no signs of toxicity.
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